<div dir="ltr"><br>We should get some glue of this type and try to glue the keys back into the centerpieces to see if we can make them work again.<div>-Borries<br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">---------- Forwarded message ---------<br>From: <strong class="gmail_sendername" dir="auto">Harrington, Nick (Nicholas) J</strong> <span dir="auto"><<a href="mailto:NJHARRINGTON@beckman.com">NJHARRINGTON@beckman.com</a>></span><br>Date: Fri, Oct 27, 2023 at 2:24 PM<br>Subject: RE: Liu samples<br>To: Borries Demeler <<a href="mailto:demeler@gmail.com">demeler@gmail.com</a>><br></div><br><br><div class="msg8357988543900003035">
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<p class="MsoNormal">Borries,<u></u><u></u></p>
<p class="MsoNormal">Slight revision, the glue used in our manufacturing process is Locktite RC 609.<u></u><u></u></p>
<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal">Thanks,<u></u><u></u></p>
<p class="MsoNormal">Nick<u></u><u></u></p>
<p class="MsoNormal"><u></u> <u></u></p>
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Confidential - Company Proprietary<br>
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<p class="MsoNormal"><b>From:</b> Harrington, Nick (Nicholas) J <br>
<b>Sent:</b> Friday, October 27, 2023 11:42 AM<br>
<b>To:</b> Borries Demeler <<a href="mailto:demeler@gmail.com" target="_blank">demeler@gmail.com</a>><br>
<b>Subject:</b> RE: Liu samples<u></u><u></u></p>
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<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal">Borries,<u></u><u></u></p>
<p class="MsoNormal">I as well as our product manager agree, it likely a glue failure. Guidance from tech support is to try and use a small amount of super glue to secure them back into the correct position. This isn’t something which we have seen. Please
use caution as to not use too much glue as it could impact the other components and their fit. FYI- 305552 is the part number for the two-sector external fill cell housing.<u></u><u></u></p>
<p class="MsoNormal"><u></u> <u></u></p>
<p class="MsoNormal">Thanks,<u></u><u></u></p>
<p class="MsoNormal">Nick<u></u><u></u></p>
<p class="MsoNormal"><u></u> <u></u></p>
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<p class="MsoNormal"><b>From:</b> Borries Demeler <<a href="mailto:demeler@gmail.com" target="_blank">demeler@gmail.com</a>>
<br>
<b>Sent:</b> Thursday, October 26, 2023 12:38 PM<br>
<b>To:</b> Harrington, Nick (Nicholas) J <<a href="mailto:NJHARRINGTON@beckman.com" target="_blank">NJHARRINGTON@beckman.com</a>><br>
<b>Subject:</b> Re: Liu samples<u></u><u></u></p>
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<p class="MsoNormal"><u></u> <u></u></p>
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<p class="MsoNormal"><span style="font-size:1.0pt;color:white">Nick, can you please let me know how I am going to get the keys re-glued into the housings? They are not consumables. They should last forever - I have housings
that are 30+ years old from the Model-E and they still have their keys properly <u></u>
<u></u></span></p>
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<p class="MsoNormal">Nick,<u></u><u></u></p>
<div>
<p class="MsoNormal">can you please let me know how I am going to get the keys re-glued into the housings? They are not consumables. They should last forever - I have housings that are 30+ years old from the Model-E and they still have their keys properly locked
in place and do not leak. This is a glue failure. There is nothing that wears out on the housings if they are properly handled. I suspect this is a batch issue, since they all have the same number stamped below the fill holes (305552).<u></u><u></u></p>
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<p class="MsoNormal"><u></u> <u></u></p>
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<p class="MsoNormal">Thanks, -Borries<u></u><u></u></p>
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<p class="MsoNormal"><u></u> <u></u></p>
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<p class="MsoNormal"><u></u> <u></u></p>
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<p class="MsoNormal"><u></u> <u></u></p>
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<p class="MsoNormal">On Tue, Oct 17, 2023 at 11:30 AM Harrington, Nick (Nicholas) J <<a href="mailto:NJHARRINGTON@beckman.com" target="_blank">NJHARRINGTON@beckman.com</a>> wrote:<u></u><u></u></p>
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<p class="MsoNormal">Borries,<u></u><u></u></p>
<p class="MsoNormal">Yes, I have been following all of email communications. I want to thank you for all the extra effort you and your team has put into this sample analysis- time, resources, and knowledge
of the limitations of DLS!! <u></u><u></u></p>
<p class="MsoNormal"> <u></u><u></u></p>
<p class="MsoNormal">I have reached out to our product manager regarding the cell housings. I have not heard anything back yet. While the cell housing and components are ‘consumables’, they are certainly
more like hardware than a traditional tube or bottle. That said, I am sure they have a certain life expectancy/warranty and retirement age. Given they are several years old, my initial guess is that they are out of the warranty period, but more to come and
I will pass on all information I receive. <u></u><u></u></p>
<p class="MsoNormal"> <u></u><u></u></p>
<p class="MsoNormal">I had heard Whitney is out on medical leave, but I do not know anything more than that. I second your feelings and hope it is something minor.
<u></u><u></u></p>
<p class="MsoNormal"> <u></u><u></u></p>
<p class="MsoNormal">Best Regards,<u></u><u></u></p>
<p class="MsoNormal">Nick<u></u><u></u></p>
<p class="MsoNormal"> <u></u><u></u></p>
<p class="MsoNormal"><u></u> <u></u></p>
<p align="center" style="margin:5.0pt;text-align:center"><span style="font-size:10.0pt;color:#d89b2b">Confidential - Company Proprietary<u></u><u></u></span></p>
<div style="border:none;border-top:solid #e1e1e1 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b>From:</b> Borries Demeler <<a href="mailto:demeler@gmail.com" target="_blank">demeler@gmail.com</a>>
<br>
<b>Sent:</b> Monday, October 16, 2023 6:23 PM<br>
<b>To:</b> Harrington, Nick (Nicholas) J <<a href="mailto:NJHARRINGTON@beckman.com" target="_blank">NJHARRINGTON@beckman.com</a>><br>
<b>Subject:</b> Liu samples<u></u><u></u></p>
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<p class="MsoNormal"> <u></u><u></u></p>
<div>
<p class="MsoNormal"><span style="font-size:1.0pt;color:white">Hi Nick, We proceeded with the experiment with Liu, in order to get closer to a point where he realizes the value of AUC. Right now, he
uses DLS, which really misleads him in terms of the quantity of the larger species he is looking for. He
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<p class="MsoNormal">Hi Nick,<u></u><u></u></p>
<div>
<p class="MsoNormal">We proceeded with the experiment with Liu, in order to get closer to a point where he realizes the value of AUC. Right now, he uses DLS, which really misleads him in terms of the
quantity of the larger species he is looking for. He doesn't quite seem to understand that the DLS completely misrepresents the composition, because the scaling is proportional to the 6th power of particle size (!), when it should be to first power of mass.<u></u><u></u></p>
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<p class="MsoNormal">So, he can't even see that there are 99% monomers in the solution, he cannot see the monomers at all!<u></u><u></u></p>
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<p class="MsoNormal"> <u></u><u></u></p>
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<p class="MsoNormal">We were able to detect a tiny amount of larger species in the mixture he sent, but it is not enough to get a good enough signal to measure molar mass. Right now I am trying to get
more concentration for the big stuff by following his recommendation to incubate the sample at 45C for several days. So, will see. Not sure if he will realize the value of an Optima AUC if the amount he tries to measure is nearly undetectable.<u></u><u></u></p>
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<p class="MsoNormal"> <u></u><u></u></p>
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<p class="MsoNormal">Another question: Did you by any chance make any progress with my question about the cell housings?<u></u><u></u></p>
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<p class="MsoNormal"> <u></u><u></u></p>
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<p class="MsoNormal">Also, do you know why Whitney is on medical leave, and when she is expected back? I hope it is nothing serious.<u></u><u></u></p>
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<p class="MsoNormal"> <u></u><u></u></p>
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<p class="MsoNormal">Thanks, -Borries<u></u><u></u></p>
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